HeyL promotes neuronal differentiation of neural progenitor cells
نویسندگان
چکیده
منابع مشابه
Activin A Promotes Neuronal Differentiation of Cerebrocortical Neural Progenitor Cells
BACKGROUND Activin A is a protein that participates principally in reproductive functions. In the adult brain, Activin is neuroprotective, but its role in brain development is still elusive. METHODOLOGY/PRINCIPAL FINDINGS We studied if Activin A influences proliferation, differentiation or survival in rat cerebrocortical neural progenitor cells (NPC). After stimulation of NPC with Activin A, ...
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Hippocampal activity influences neurogenesis in the adult dentate gyrus; however, little is known about the involvement of the hippocampal circuitry in this process. In the subgranular zone of the adult dentate gyrus, neurogenesis involves a series of differentiation steps from radial glia-like stem/progenitor (type-1) cells, to transiently amplifying neuronal progenitor (type-2) cells, to post...
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In regions of adult neurogenesis, neural progenitor cells (NPCs) are found in close proximity to blood vessels within a so-called 'vascular niche'. Neurogenesis is linked to angiogenesis via certain growth factors. We propose that angiopoietin-1 (Ang1), which is similar to VEGF, has a unique role in neurogenesis independent of its role in angiogenesis. In this study, primary cultures of NPCs we...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2011
ISSN: 0360-4012
DOI: 10.1002/jnr.22562